Identification of a new caspase homologue: caspase-14
نویسندگان
چکیده
منابع مشابه
New Member of the Caspase Family Identification and Characterization of Murine Caspase-14, a Updated Version
We report here the identification and characterization of a new mem ber of the mouse caspase family, named caspase-14. Northern blot analysis of mRNA from various tissues with caspase-14-specific probe showed a major transcript size of —¿ 2.4 kb and variant transcripts of 2.0 kb and 1.5 kb. The major transcript is detected mainly in the liver and to a lesser extent in the brain and kidney. Ca...
متن کاملIdentification and Characterization of Murine Caspase-14, a New Member of the Caspase Family1
We report here the identification and characterization of a new mem ber of the mouse caspase family, named caspase-14. Northern blot analysis of mRNA from various tissues with caspase-14-specific probe showed a major transcript size of —¿ 2.4 kb and variant transcripts of 2.0 kb and 1.5 kb. The major transcript is detected mainly in the liver and to a lesser extent in the brain and kidney. Ca...
متن کاملCaspase-14 reveals its secrets
Caspase-14 is a unique member of the evolutionarily conserved family of cysteinyl aspartate-specific proteinases, which are mainly involved in inflammation and apoptosis. However, recent evidence also implicates these proteases in proliferation and differentiation. Although most caspases are ubiquitously expressed, caspase-14 expression is confined mainly to cornifying epithelia, such as the sk...
متن کاملFunction of caspase-14 in trophoblast differentiation
BACKGROUND Within the human placenta, the cytotrophoblast consists of a proliferative pool of progenitor cells which differentiate to replenish the overlying continuous, multi-nucleated syncytiotrophoblast, which forms the barrier between the maternal and fetal tissues. Disruption to trophoblast differentiation and function may result in impaired fetal development and preeclampsia. Caspase-14 e...
متن کاملCaspase-14: A novel caspase in the retina with a potential role in diabetic retinopathy
PURPOSE The purpose of this study was to evaluate caspase-14 expression in the retina under normal and diabetic conditions, and to determine whether caspase-14 contributes to retinal microvascular cell death under high glucose conditions. METHODS Quantitative real-time polymerase chain reaction and western blot analysis were used to evaluate caspase-14 expression in retinal cells, including p...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 1998
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4400444